Mulberry Orthologous and Paralogous Groups were build from predicted protein sequences of Morus notabilis combined with Arabidopsis thaliana, Fragaria vesca, Malus domestica and Populus trichocarp, using OrthoMCL 2.0 under threshold of E-value 1e-6 and overlap 50%. Totally, 24065 groups were clustered from 231712 proteins. Protein sequences of the later four plants were downloaded from the Arabidopsis Information Resource (TAIR) and the U.S. Department of Energy (DOE) Joint Genome Institute (JGI). The download address and data version are Arabidopsis thaliana v10, Fragaria vesca v9.0, Malus domestica v9.0 and Populus trichocarp v9.0, respectively.